KLF, together with the APAC HPV Coalition and Yokohama University, collaborated on a pilot intervention to address Japan’s low HPV vaccination rates after a decade-long suspension of government recommendations. The study highlights the promise of web-based video interventions in driving catch-up HPV vaccination in Japan. Significant subgroup responses reveal fresh opportunities for tailored strategies. This is a forward-looking read for clinicians and policymakers aiming to enhance HPV vaccination programs with innovative, digital-first approaches.